HIV 1 epidemiology, pathophysiology and transmission


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Diseases & Conditions HIV/AIDS HIV Replication Cycle This infographic illustrates the HIV replication cycle, which begins when HIV fuses with the surface of the host cell. A capsid containing the virus's genome and proteins then enters the cell.


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Diagram of an HIV virion structure Scanning electron micrograph of HIV-1, colored green, budding from a cultured lymphocyte. HIV is the cause of the spectrum of disease known as HIV/AIDS. HIV is a retrovirus that primarily infects components of the human immune system such as CD4 + T cells, macrophages and dendritic cells.


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From Wikipedia, the free encyclopedia HIV is commonly transmitted via unprotected sexual activity, blood transfusions, hypodermic needles, and from mother to child. Upon acquisition of the virus, the virus replicates inside and kills T helper cells, which are required for almost all adaptive immune responses.


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Infection with HIV (human immunodeficiency virus) can lead to AIDS (acquired immunodeficiency syndrome). AIDS results in a gradual and persistent decline and failure of the immune system, resulting in a heightened risk of life-threatening infection and cancers.. In the majority of cases, HIV is a sexually transmitted infection.


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HIV/AIDS is an exceptional epidemic that demands an exceptional response. Much progress has been made in a short space of time, despite many scientific and programmatic challenges (figure 6). In the absence of a protective vaccine or a cure, prevention and access to antiretroviral treatments are the best options to slow down the HIV-1 pandemic.


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The seven stages of the HIV life cycle are: 1) binding, 2) fusion, 3) reverse transcription, 4) integration, 5) replication, 6) assembly, and 7) budding. To understand each stage in the HIV life cycle, it helps to first imagine what HIV looks like.


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Diagram of HIV Structure of the immature HIV-1 capsid in intact virus particles A diagram of the HIV spike protein (green), with the fusion peptide epitope highlighted in red, and a broadly neutralizing antibody (yellow) binding to the fusion peptide


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The indicators and questions in this document are designed for use by national AIDS programmes and partners to assess the state of a country's HIV and AIDS response, and to measure progress towards achieving national HIV targets. Countries are encouraged to integrate these indicators and questions into their ongoing monitoring efforts and to report comprehensive national data


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What Is HIV? HIV (human immunodeficiency virus) is a virus that attacks cells that help the body fight infection, making a person more vulnerable to other infections and diseases.It is spread by contact with certain bodily fluids of a person with HIV, most commonly during unprotected sex (sex without a condom or HIV medicine to prevent or treat HIV), or through sharing injection drug equipment.


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This diagram is based on a fantastic map of the HIV-1, HIV-2, and SIV genomes, available at. This is a lot fewer spikes than you'll see on most diagrams of HIV! There's a bit of confusion since some studies have decided that HIV particles normally have 72 spikes, whilst some other studies have decided that they have normally no more than.


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The human immunodeficiency virus (HIV) is an enveloped retrovirus that contains 2 copies of a single-stranded RNA genome. It causes the acquired immunodeficiency syndrome (AIDS) that is the last stage of HIV disease. Two to four weeks after HIV enters the body, the patient may complain of symptoms of primary infection.[1] After that, a long chronic HIV infection occurs, which can last for.


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Viral Attachment Once HIV enters the body (typically through sexual contact, blood exposure, or mother-to-child transmission), it seeks out a host cell in order to reproduce. The host in the case is the CD4 T-cell used to signal an immune defense. In order to infect the cell, HIV must attach itself by way of a lock-and-key type system.


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Data collection. China established the HIV/AIDS case reporting system in 1985, when the first foreign case was diagnosed. It was a nationwide real-time reporting system, and developed into web-based Comprehensive Response Information Management System (CRIMS) in 2005 [].China's laws on the prevention and treatment of infectious diseases designates AIDS as a class B notifiable infectious disease.


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Tables, diagrams and illustrations The following graphic images open as individual images and can be enlarged when printing to use as handouts. Cartoon graphics Ways that HIV is not transmitted HIV testing: feelings of fear, anxiety and guilt How can my partner test positive and I test negative? Figures Figure 1: Common risks for transmission


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Without treatment with HIV medicines, HIV infection advances in stages, getting worse over time. The three stages of HIV infection are (1) acute HIV infection, (2) chronic HIV infection, and (3) acquired immunodeficiency syndrome (AIDS). There is no cure for HIV, but treatment with HIV medicines (called antiretroviral therapy or ART) can slow or prevent HIV from advancing from one stage to the.


HIV 1 epidemiology, pathophysiology and transmission

The most significant of these has been HIV-1, which causes exceptionally high mortality rates through AIDS. The number of people living with HIV is currently estimated to be in excess of 33 million, with 2.7 million new infections and 2 million AIDS-related deaths in 2008 (UNAIDS 2009). HIV-1 is, therefore, one of the most studied viruses and.